“Tip 5 Hipersensitivite; Receptor aracılı ADR olarak da bilinir. Tip 2 içinde sitotoksik olmayan otoimmün ADR ler olarak kabul edilir. Graves’ disease, Myasthenia gravis, Pernicious anemia
Graves’ disease Myasthenia gravis Pernicious anemia
Tıbbi Patoloji
Tip 2 Hipersensitivite “Antibody-dependent cellular cytotoxicity (ADCC)”
Disease Autoantibody target Autoimmune hemolytic anemia Red blood cells Goodpasture syndrome Glomerular basement membrane Graves disease Thyroid stimulating hormone receptor Immune thrombocytopenia Platelets Myasthenia gravis Muscle acetylcholine receptor Type II/ADCC IgG, IgM I-Foreign Hemolytic disease of the newborn II-Autoimmune 1-Cytotoxic Autoimmune hemolytic anemia Bullous pemphigoid Goodpasture syndrome Guillain–Barré syndrome Immune thrombocytopenic purpura Pemphigus vulgaris Rheumatic … Devamını oku
Tip 3 Hipersensitivite “immune complexes (antigen-antibody complexes)”
Systemic lupus erythematosus Nuclear antigens Nephritis Skin lesions Arthritis Rheumatoid Arthritis Antibody complexes: specifically IgM to IgG Arthritis IgA nephropathy IgA antibodies with O-glycans deficient in galactose[2] Nephritis Post-streptococca glomerulonephritis Streptococcal cell wall antigens Nephritis Polyarteritis nodosa Hepatitis B virus surface antigen Systemic vasculitis Reactive arthritis Several bacterial antigens Acute arthritis Serum sickness Various Arthritis Vasculitis Nephritis Arthus … Devamını oku
T Hücre aracılı Hastalıklar (Tip 4 Hipersensitivite), delayed-type hypersensitivity; DTH; cell-mediated hypersensitivity
Disease Target antigen Effects Allergic contact dermatitis Environmental chemicals, like urushiol (from poison ivy and poison oak), metals (e.g. nickel), topical medication epidermal necrosis, inflammation, skin rash, and blisters Autoimmune myocarditis Myosin heavy chain protein Cardiomyopathy Diabetes mellitus type 1 Pancreatic beta cell proteins (possibly insulin, glutamate decarboxylase) Insulitis, beta cell destruction Granulomas Various, depending on underlying disease Walled-off lesion containing macrophages and other cells Some peripheral neuropathies Schwann cell antigen Neuritis, paralysis Hashimoto’s thyroiditis Thyroglobulin antigen … Devamını oku
Menetrier adenokanser riskini arttırır
Menetrier Hastalığı; Yüzey epitelinde büyüme faktörlerinin(TGF- alfa) aşırı ekspresyonu nedeniyle oluşur. Özellikle korpus ve fundus etkilenir. Glandlarda tirbüşon görünümü ve kistik dilatasyon sonrasında gland atrofisi karşımıza çıkar. Protein kaybettiren enteropati yapar. Asit salgısı azalır. Mide kanseri riski artmıştır Menetrier hastalığı ile ilgili aşağıdaki ifadelerden hangisi yanlıştır? A) Mide kanseri riski artmıştır.B) TGF-alfa aşırı ekspresyonu sonucu … Devamını oku