| Disease | Target antigen | Effects |
| Allergic contact dermatitis | Environmental chemicals, like urushiol (from poison ivy and poison oak), metals (e.g. nickel), topical medication | epidermal necrosis, inflammation, skin rash, and blisters |
| Autoimmune myocarditis | Myosin heavy chain protein | Cardiomyopathy |
| Diabetes mellitus type 1 | Pancreatic beta cell proteins (possibly insulin, glutamate decarboxylase) | Insulitis, beta cell destruction |
| Granulomas | Various, depending on underlying disease | Walled-off lesion containing macrophages and other cells |
| Some peripheral neuropathies | Schwann cell antigen | Neuritis, paralysis |
| Hashimoto’s thyroiditis | Thyroglobulin antigen | Hypothyroidism, hard goiter, follicular thymitis |
| Inflammatory bowel disease | Enteric microbiota and/or self antigens | Hyperactivation of T-cells, cytokine release, recruitment of macrophages and other immune cells, inflammation |
| Multiple sclerosis | Myelin antigens (e.g., myelin basic protein) | Myelin destruction, inflammation |
| Rheumatoid arthritis | Possibly collagen and/or citrullinated self proteins | Chronic arthritis, inflammation, destruction of articular cartilage and bone |
| Tuberculin reaction (Mantoux test) | Tuberculin | Induration and erythema around injection site indicates previous exposure |
An example of a tuberculosis (TB) infection
Some other clinical examples:
Urushiol-induced contact dermatitis
Chronic transplant rejection
Coeliac disease
Giant cell arteritis
Graft-versus-host disease
Leprosy
| Type IV/cell-mediated (T cells) | I-Foreign Allergic contact dermatitis Mantoux test II-Autoimmune Coeliac disease Giant cell arteritis Hashimoto’s thyroiditis Multiple sclerosis Postorgasmic illness syndrome Reactive arthritis Type 1 diabetes III-GVHD Transfusion-associated graft-versus-host disease |