Tıbbi Patoloji

PCDs/PP “plasma cell dyscrasias/ Monoclonal gammopathy, paraproteinemia” 1-Plasmacytoma 2-Multiple myeloma (Plasma cell leukemia) 3-MGUS 4-IgM (Macroglobulinemia/Waldenström macroglobulinemia) 5-Heavy chain (Heavy chain disease) 6-Light chain (Primary amyloidosis)

1-Germinal center/follicular B cell (Follicular, Burkitt’s, GCB DLBCL”Germinal center B-cell like diffuse large B-cell lymphoma“, Primary cutaneous follicle center lymphoma) 2-Primary mediastinal B-cell lymphoma 3-Marginal zone/marginal zone B-cell (Splenic marginal zone, MALT “mucosa-associated lymphoid tissue“, Nodal marginal zone, Primary cutaneous marginal zone lymphoma)

CD22⁺ ve İlgili Patolojiler Marker Hücre Tipi / Klinik İlişki Tipik Hastalık / Patoloji CD22⁺ B-hücresi marker’ı Prolymphocytic Leukemia (B-PLL) → agresif B hücreli lösemi CD11c⁺ B-hücrelerde, özellikle aktivasyon marker’ı Hairy Cell Leukemia (HCL) → tipik olarak TRAP (+), pancytopeni, splenomegali Diğer önemli markerler CD19⁺, CD20⁺ → çoğu B-hücresi neoplazmı CD5⁺ → CLL, Mantle cell … Devamını oku