NO sentazın kofaktörleri; NADP, FMN, FAD, Ca / kalmodülin sistemi, Hem ve tetrahidrobiopterindir

Tetrahydrobiopterin (BH4), nicotinamide adenine dinucleotide phosphate, flavin adenine dinucleotide, flavin mononucleotide, calcium (Ca2 +), calmodulin, and heme are all NOS cofactors