Aşağıdaki reseptörlerden hangisinin bloke edilmesi ile antiemetik etki elde edilemez?
A) Kannabinoid CB1 *********
B) Dopamin D2
C) Substans P NK1
D) Serotonin 5-HT3
E) Asetilkolin M1
Antiemetik Etki Mekanizmaları
Serotonin 5-HT3 reseptörlerinin bloke edilmesi
Muskarinik M1 reseptörlerinin bloke edilmesi
Histamin H1 reseptörlerinin bloke edilmesi
Substans P NK1 reseptörlerinin bloke edilmesi
Dopamin D2 reseptörlerinin bloke edilmesi
Kannabinoid CB1 reseptörlerinin aktive edilmesi
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1-5-HT3 receptor antagonists block
Dolasetron (Anzemet)
Granisetron (Kytril, Sancuso) Ondansetron (Zofran)
Tropisetron (Setrovel, Navoban)
Palonosetron (Aloxi)
2-Dopamine antagonists
Amisulpride (Barhemsys), administered by intravenous injection.
Domperidone (Motilium)
Droperidol
Olanzapine (Zyprexa)
Haloperidol (limited in usefulness by extra-pyramidal and sedative side-effects)
Alizapride
Prochlorperazine (Compazine, Stemzine, Buccastem, Stemetil, Phenotil)
Chlorpromazine (Use limited by sedating properties)
Metoclopramide
3-NK1 receptor antagonist
Aprepitant (Emend)
Casopitant
Rolapitant (Varubi)
4-Antihistamines (H1 histamine receptor antagonists)
Cinnarizine
Cyclizine
Diphenhydramine (Benadryl)
Dimenhydrinate (Gravol, Dramamine)
Doxylamine (Bonjesta, Unisom)
Mirtazapine (Remeron)
Meclizine (Bonine, Antivert)
Promethazine
Hydroxyzine (Vistaril)
5-Cannabinoids
Cannabis
Nabilone
Dronabinol (Marinol/Syndros)
Synthetic cannabinoids Nabilone (Cesamet) ve JWH series.
Sativex
6-Benzodiazepines (GABA receptor positive allosteric modulators)
Midazolam (Versed)
Lorazepam (Ativan)
7-Anticholinergics
Hyoscine (scopolamine)
Atropine
8-Steroids
Dexamethasone (Decadron)
9-Other
Trimethobenzamide
Ginger
Emetrol
Propofol i
Peppermint
Muscimol
Ajwain