Renin inhibitors (“-kiren”)
Renin inhibitörleri, reninin aktif enzimatik bölgesini bloke eden, böylece anjiyotensinojenden anjiyotensin I üretimini modüle eden ilaçlardır
1-Aliskiren (+amlodipine, +HCT, +amlodipine and HCT)
2-Remikiren
3-Ciprokiren
4-Enalkiren
5-Zankiren
6-Terlakiren
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1-Pepstatin – the first renin inhibitor
Pepstatin was the first synthetic renin inhibitor. Originally, it was thought to be effective in the treatment of duodenal ulcers, and went through clinical trials, but had no success.
2-First generation: peptide analogues: Enalkiren
3-Second generation: peptidomimetics; Remikiren, a second-generation renin inhibitor
4-Third generation: non-peptides; Aliskiren, the third-generation renin inhibitör
A-Aliskiren, renin inhibitörü
B-Kaptopril, ACE (yani diğer adı ile kininaz II) inhibitörü
C-Losartan, AT2 reseptör blokeri
D-Spironolakton, Aldosteron antagonisti
